Larotrectinib

Active Ingredient: Larotrectinib
Form: Capsule
Brand Name: Vitrakvi
Generic Name: Tractoni
Generic Manufacturer: Ziska Pharmaceuticals

Indications:
Vitrakvi is a targeted anticancer therapy that inhibits neurotrophic tyrosine receptor kinase (NTRK) fusion proteins. It is the world’s first approved tumor-agnostic oral TRK inhibitor, indicated for the treatment of patients with solid tumors harboring an NTRK gene fusion, regardless of the tumor’s site of origin.

Dosage and Administration:
For patients with a body surface area ≥ 1 m², the recommended dose is 100 mg orally per day, divided into two doses. For those with a body surface area < 1 m², the recommended dose is 100 mg/m² per day, also divided into two doses. Capsules should be swallowed whole. If a dose is missed, do not make it up—continue with the next scheduled dose.

Common Side Effects:
Neurotoxicity and hepatotoxicity are the most common side effects.

Storage:
Store below 30°C in a cool, dry place away from direct sunlight. Keep out of reach of children.

Frequently Asked Questions

Q: What is the relationship between Vitrakvi and Larotrectinib?
A: Vitrakvi is the brand name registered by the original manufacturer. Larotrectinib is the active ingredient.

Q: Is the Vitrakvi sold by Mediva Rx the original brand-name drug?
A: No. Mediva Rx offers a high-quality generic version manufactured by one of Bangladesh’s top 10 pharmaceutical companies. It contains the same active ingredient and therapeutic effect as the original and is tested and approved by the Directorate General of Drug Administration (DGDA).

Q: Is the manufacturer of the Vitrakvi generic version reliable?
A: Yes. We work with Ziska Pharmaceuticals, one of Bangladesh’s leading pharmaceutical companies, with in-house R&D, production, and quality control labs. They are certified to meet international pharmaceutical manufacturing standards. You can purchase with confidence.

Disclaimer:
This information is for reference only. Treatment decisions should always be made under the guidance of a licensed physician and based on the official prescribing information and current clinical evidence.

Drug Instructions (Package Insert):
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